METHOD FOR PRODUCING PYRIDO[1,2-A] PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS

METHOD FOR PRODUCING PYRIDO[1,2-A] PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUNDS

PCT No. PCT/HU92/00031 Sec. 371 Date Feb. 10, 1994 Sec. 102(e) Date Feb. 10, 1994 PCT Filed Aug. 13, 1992 PCT Pub. No. WO93/04065 PCT Pub. Date Mar. 4, 1993.4-oxo-4H-pyrido[1,2-a]-pyrimidines are disclosed of the formula (I) and/or (II) wherein R is a C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-7 cycloa...

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Hauptverfasser: HERMECZ,ISTVAN, KAPUI,ZOLTAN, PAPP,ILONA, HORVATH,AGNES, BALOGH,MARIA, TARDOS,LASZLO, SIPOS,JUDIT, VASVARINE DEBRECZY,LELLE, KNOLL,JOZSEF, GYIRES,KLARA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PCT No. PCT/HU92/00031 Sec. 371 Date Feb. 10, 1994 Sec. 102(e) Date Feb. 10, 1994 PCT Filed Aug. 13, 1992 PCT Pub. No. WO93/04065 PCT Pub. Date Mar. 4, 1993.4-oxo-4H-pyrido[1,2-a]-pyrimidines are disclosed of the formula (I) and/or (II) wherein R is a C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C3-7 cycloalkyl, -(CH2)n-COOR3 wherein R3 is C1 to C4 alkyl and n is 0 or 1 or a C7-8 aralkyl group, optionally substituted by one or more halogen atom(s), or by a nitro-group, R1 is a hydrogen atom or a C1-4 alkyl group, and salts thereof, as well as a process for their preparation, and pharmaceutical compositions containing them. These compounds are therapeutically useful as gastroprotectives in the treatment and prevention of ulcer.