BIOACTIVE COMPOSITIONS AND PROCESS FOR FORMING BIOACTIVE COATINGS

An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the sol...

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Hauptverfasser: CHANDRASEKHARAN,RAMACHANDRAN,US, GOLDBERG,ARTHUR H.,US, AMIDON,GORDON L.,US
Format: Patent
Sprache:eng
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Zusammenfassung:An improved bioactive agent delivery composition and method of application are described. The composition comprises a bioactive agent, a hydrophilic polymer in an incompletely hydrated state and a substantially water-miscible solvent system. The agent and polymer are essentially dissolved in the solvent system to form a sprayable composition having a viscosity of less than 350 cP. Upon dilution with water, the viscosity of the composition increases to in excess of 1000 cP to produce a retentive coating at the site of application which provides enhanced bioavailability of the agent.