PROCESS FOR PRODUCING PIPEIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

PROCESS FOR PRODUCING PIPEIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS

3-piperidino-4-hydroxychroman derivs. of formula (I) and their salts are new, where A and B = H or A with B = -CH2CH2-. X = CH2 or O. X1 = H or OH. Z = H, F, Cl, Br or OH. Z1 = H, F, Cl, Br or 1-3C alkyl. n = O or 1; m = 0 or 1-6. When X = 0 (I) pref has cis stereochemistry. (I) are prepd. by hydrid...

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Bibliographische Detailangaben
1. Verfasser: BUTLER,TODD W.,US
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:3-piperidino-4-hydroxychroman derivs. of formula (I) and their salts are new, where A and B = H or A with B = -CH2CH2-. X = CH2 or O. X1 = H or OH. Z = H, F, Cl, Br or OH. Z1 = H, F, Cl, Br or 1-3C alkyl. n = O or 1; m = 0 or 1-6. When X = 0 (I) pref has cis stereochemistry. (I) are prepd. by hydride redn. of a suitable alpha-aminoketone, using e.g. NaBH4 in THF at -15 to 15 deg.C.