PROCESS FOR PRODUCING CRISTALLINE H-ARG-LYS-ASP-OH ABD H-ARG-LYS-ASP-VAL-OH OF HIGH PURITY

PROCESS FOR PRODUCING CRISTALLINE H-ARG-LYS-ASP-OH ABD H-ARG-LYS-ASP-VAL-OH OF HIGH PURITY

The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: UEBERHARDT,TAMASNE,HU, SZPORNY,LASZLO,HU, MUCK,ANDRASNE,HU, SCHOEN,ISTVAN,HU, LORANTNE MAREK,GIZELLA,HU, UEBERHARDT,TAMAS,HU, DENES,LASZLO,HU, IVANYI,GEZA,HU, NYEKI,OLGA,HU, HAJOS,GYOERGY,HU, KOVACS,LAJOS,HU, GAZDAG,MARIA,HU, PETER,IMRE,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml, then the crystallized peptide is separated from the crystalline suspension, preferably after cooling. Pharmaceutical compositions containing the crystalline forms of these peptides are also described.