PROCESS FOR PRODUCING N-/BENZOYL/OXY/CARBONYL/-5-ETHYL-1,2-DIHYDROPYRIDINE

PROCESS FOR PRODUCING N-/BENZOYL/OXY/CARBONYL/-5-ETHYL-1,2-DIHYDROPYRIDINE

N-(benzyl-oxy-carbonyl)-5-ethyl-1, 2-di: hydro-pyridine (1), an intermediate for katarautin, is prepd from 2-benzyl-2-ethyl-1,2,5,6-tetra-hydropyrine (11) and benzyl-chloro-formate at 50-140 deg.C in an inert apolar solvent pref an aromatic hydrocarbon to yield 1-(benzyl-oxy-carbonyl)-3-ethyl-1,2, 5...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: FEKETE,GYOERGY,HU, BOELCSKEY,HEDVIG,HU, BALAZS,MIHALY,HU, STEFKO,BELA,HU, SZANTAY,CSABA,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:N-(benzyl-oxy-carbonyl)-5-ethyl-1, 2-di: hydro-pyridine (1), an intermediate for katarautin, is prepd from 2-benzyl-2-ethyl-1,2,5,6-tetra-hydropyrine (11) and benzyl-chloro-formate at 50-140 deg.C in an inert apolar solvent pref an aromatic hydrocarbon to yield 1-(benzyl-oxy-carbonyl)-3-ethyl-1,2, 5,6-tetra: hydro-pyridine (111). (111) is treated with bromine at 0-30 deg.C in an inert apolar solvent pref chlorinated hydrocarbon to 1-(benzyl-oxy-carbonyl)-trans-3, 4-di:bromo-3-ethyl-piperidine (IV). (IV) is dehydro-brominated with a conventional reagent pref 1,4-di:aza-bi:cyclo-(2,2,2)-octane in dipolar aprotic solvent as di:methyl-formamide or aceto-nitrile prod (1) is isolated.