PROCESS FOR PREPARING ALPHA-AMINO-P-HYDROXY-BENZYL-PENICILLINE-TRIHYDRATE
During an improved prepn. of alpha-amino-p-hydroxy -benzylpenicillin-trihydrate, (-5)-(-10 deg.) C is used for a rapid and stable formation of the mixed anhydride. At the end of the reaction sequence but prior to the splitting off the protective gp. hydrochloric acid is added to the reaction mix at...
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