PROCESS FOR PREPARING ALPHA-AMINO-P-HYDROXY-BENZYL-PENICILLINE-TRIHYDRATE

PROCESS FOR PREPARING ALPHA-AMINO-P-HYDROXY-BENZYL-PENICILLINE-TRIHYDRATE

During an improved prepn. of alpha-amino-p-hydroxy -benzylpenicillin-trihydrate, (-5)-(-10 deg.) C is used for a rapid and stable formation of the mixed anhydride. At the end of the reaction sequence but prior to the splitting off the protective gp. hydrochloric acid is added to the reaction mix at...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KARACSONYI,NEE KISS,ANIKO,HU, ELEK,SANDOR,HU, NAGY,JOZSEF,HU, ANTAL,ERNOE,HU, KELEN,TIBOR,HU, BORBELY,SZABOLCS,HU, BALINT,MARTA,HU, MELCZER,ISTVAN,HU, KOCSAR,BARNA,HU, NEMES,SANDOR,HU, ZSUGA,MIKLOS,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:During an improved prepn. of alpha-amino-p-hydroxy -benzylpenicillin-trihydrate, (-5)-(-10 deg.) C is used for a rapid and stable formation of the mixed anhydride. At the end of the reaction sequence but prior to the splitting off the protective gp. hydrochloric acid is added to the reaction mix at (-55)-(-75) deg. C to avoid an acidity excess. Following the mixing stage, the temp. is raised to 0 deg. C, the optimum temp. for hydrolysis. Using above method the product is obtd. at 80% yield and is of pharmacopoeial quality.