METHOD FOR RADIOIMMUNOLOGIC DETECTING CONTENT OF ADENOSIN -3',5'- CYCLOPHOSPHATE AND MAKING RADIOLIGAND USED FOR THIS

METHOD FOR RADIOIMMUNOLOGIC DETECTING CONTENT OF ADENOSIN -3',5'- CYCLOPHOSPHATE AND MAKING RADIOLIGAND USED FOR THIS

Method is based on an antigen-autitest reaction used for the detm. of adenosine 3'-5'cyclo-phosphate (C-AMP) concn. employs a radio ligand of a novel structure. The ligand is a 2'-O-(2'',3''-3H2-) succinyl C-AMP deriv. (I) exhibiting excellent moler activity acid e...

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Bibliographische Detailangaben
Hauptverfasser: SEREGI,ANDRAS,HU, BENKOE,JULIANNA,HU, MUCHA,ISTVAN,HU, SERFOEZOE,PETER,HU, TANACS,BELA,HU
Format: Patent
Sprache:eng
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Zusammenfassung:Method is based on an antigen-autitest reaction used for the detm. of adenosine 3'-5'cyclo-phosphate (C-AMP) concn. employs a radio ligand of a novel structure. The ligand is a 2'-O-(2'',3''-3H2-) succinyl C-AMP deriv. (I) exhibiting excellent moler activity acid extended half life. - R is a hydroxy or L-(3,5-3H)Me-tyrosine group. (I) is prepd. by reaction of tritium-contg. succinic acid anhydride (II) and adenosine 3,-5' cyclophosphate or its salts. A product (1A) being similar to (I) can if required react with a tyrosine deriv.