NEW PROCESS FOR THE PRODUCTION OF CURATIVE BENZOTHIAZINE-DIOXIDE-DERIVATIVES, AND OF NEW INTERMEDIATE PRODUCT THEREOF

NEW PROCESS FOR THE PRODUCTION OF CURATIVE BENZOTHIAZINE-DIOXIDE-DERIVATIVES, AND OF NEW INTERMEDIATE PRODUCT THEREOF

Method for the preparation of a 2-methyl-4-hydroxy-2H-1,2-benzotiacin-1,1-dioxide-3- (N-2-piridyl) -carboxamide. You considered to reaction 2-methyl-2 acid -mesiloxy-2H-1,2-benzotiacin-1,1-dioxido-3-carboxylic of formula (II) with 2-aminopyridine in the presence of tionillo chloride in an inert solv...

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Hauptverfasser: KAIRISALO,PEKKA,FI, KARHU,MATTI,FI, KURIMO,IRMA R,FI, PIPPURI,AINO K,FI, JOHANSSON,MAGUS E,FI, NORE,PENTTI T,FI, HONKANEN,ERKKI J,FI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Method for the preparation of a 2-methyl-4-hydroxy-2H-1,2-benzotiacin-1,1-dioxide-3- (N-2-piridyl) -carboxamide. You considered to reaction 2-methyl-2 acid -mesiloxy-2H-1,2-benzotiacin-1,1-dioxido-3-carboxylic of formula (II) with 2-aminopyridine in the presence of tionillo chloride in an inert solvent to prepare the desired compound of formula (I). The reaction temperature is included between 40 and 80 jc and as solitary inert, chloride hydrocarbons are used, using a time of 2 to 3 hours. (Machine-translation by Google Translate, not legally binding)