6-METHYL-2-(4-METHYL-PHENYL)-IMIDAZOLE-[1,2-A]PYRIMIDINE-3-ACETIC ACID-ESTERS AND PROCESS FOR THEIR PREPARATION

6-METHYL-2-(4-METHYL-PHENYL)-IMIDAZOLE-[1,2-A]PYRIMIDINE-3-ACETIC ACID-ESTERS AND PROCESS FOR THEIR PREPARATION

6-methyl-2-(4-methyl-phenyl)-imidazo(1,2- a)pyrimidine-3-(N,N-dimethyl-acetamide) (I) is prepared by reaction of an acetate ester (II) with dimethylamine in a polar aprotic solvent. Preparation of a compound of formula (I), or an acid addition salt of (I), comprises: (a) reaction of an ester compoun...

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Bibliographische Detailangaben
Hauptverfasser: PONGO LASZLO, NAGY KALMAN, RIVO ENDRE, REITER JOZSEF, SIMIG GYULA, HOFFMANNE FEKETE VALERIA, KONCZ LASZLO, VERECZKEYNE DONATH GYOERGYI, TOEMPE PETER
Format: Patent
Sprache:eng
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Zusammenfassung:6-methyl-2-(4-methyl-phenyl)-imidazo(1,2- a)pyrimidine-3-(N,N-dimethyl-acetamide) (I) is prepared by reaction of an acetate ester (II) with dimethylamine in a polar aprotic solvent. Preparation of a compound of formula (I), or an acid addition salt of (I), comprises: (a) reaction of an ester compound of formula (II) with dimethylamine in a polar aprotic solvent; and optionally (b) converting the product (I) into an acid addition salt. R = lower alkyl or phenyl-lower alky.l Independent claims are included for: (i) esters (II), with the exception of (II; R = ethyl), and (ii) crystalline esters of formula (II).