System and methods for real-time synchronization of biological data with millisecond time accuracy

The present invention relates to a system (1) for synchronization of biological data in real time with millisecond temporal precision. The system comprises a screen (10) for displaying visual stimuli; a control unit (20) connected to the screen (10) for transmitting visual stimuli; an optical sensor (30) connected to the screen (10) for detecting visual stimuli; a neuronal activity measuring device (40) with an internal clock (41), which is connected to the control unit (20) for transmitting neuronal activity registered by the internal clock (41); feedback device (50), which comprises a plurality of push buttons (51) suitable for detecting responses of a subject to visual stimuli, and a stop button (52) suitable for stopping the display of visual stimuli. The system (1) is characterized by the fact that it comprises a microcontroller (60) with a real-time clock (61), which is connected to the optical sensor (30) and the feedback device (50) for registering their events in real time, with millisecond precision, using the real-time clock (61), wherein the microcontroller (60) is capable of generating a synchronizing time signal for each registered event, and the microcontroller (60) is connected to the control unit (20) for transmitting the registered events and their associated synchronizing time signals; wherein the control unit (20) is configured such that it is suitable for receiving each event registered by the real-time clock (61) and the neuronal activity events registered by the internal clock (41), as well as for their correlation based on the synchronizing time signals. The system further comprises optoisolator (70) suitable for providing the electrical isolation of the connection between the microcontroller (60) and the neuronal activity measuring device (40). The present invention also relates to methods for a system (1) for synchronization of biological data of a subject in real time with millisecond temporal precision.