A production method and a new crystalline from of an intermediate of synthesis of ticagrelor

A production method and a new crystalline from of an intermediate of synthesis of ticagrelor

The invention relates to preparation of ticagrelor of formula I and comprises a reaction of a compound of formula IV with a deprotection agent in a solvent to a compound of formula V, which is advantageously isolated by crystallization and subsequently used for the preparation of ticagrelor. The sub...

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Hauptverfasser: DAMMER ONDREJ, VYSLOUZIL ROSTISLAV, OBADALOVA IVA, STEHLI�EK IVAN, STRELEC IVO, RIHA JAROSLAV, VOSLAR MICHAL, HES TOMAS
Format: Patent
Sprache:eng ; hun
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Zusammenfassung:The invention relates to preparation of ticagrelor of formula I and comprises a reaction of a compound of formula IV with a deprotection agent in a solvent to a compound of formula V, which is advantageously isolated by crystallization and subsequently used for the preparation of ticagrelor. The substituent R in formulae IV and V is CH2CH2OH, CH2COOH, or CH2COOR1; R1 is a branched or unbranched R1-C4 alkyl; and X is NH2, NO2f or NHCHO.