Intermediate of baricitinib and process for its preparation
Method and intermediates are disclosed for the production of baricitinib. According to the novel method baricitinib may be produced preferably via the intermediates ieri-butyl-3- (cyanomethyl)-3-[4-(7-{[(2,2-dimethylpropanoyl)oxy]methyl}-7H-pyrrolo[2,3-d]pirimidin-4- yl)- lH-pyrazol- l-yl]azetidine-...
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| creator | dr. Volk Balazs Tothne Dr. Lauritz Maria dr. Simig Gyula Kataine Fadgyas Katalin dr. Nagy Tamas dr. Dancso Andras dr. Szabo Eva dr. Sipos Eva |
| description | Method and intermediates are disclosed for the production of baricitinib. According to the novel method baricitinib may be produced preferably via the intermediates ieri-butyl-3- (cyanomethyl)-3-[4-(7-{[(2,2-dimethylpropanoyl)oxy]methyl}-7H-pyrrolo[2,3-d]pirimidin-4- yl)- lH-pyrazol- l-yl]azetidine- l-carboxylate and 4-{ 1-[3-(cyanomethyl)azetidin-3-yl]-1H- pyrazol-4-yl}-7H-pyrrolo[2,3-d]pirimidin-7-yl)methyl 2,2-dimethylpropanoate. |
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| title | Intermediate of baricitinib and process for its preparation |
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