Intermediate of baricitinib and process for its preparation

Intermediate of baricitinib and process for its preparation

Method and intermediates are disclosed for the production of baricitinib. According to the novel method baricitinib may be produced preferably via the intermediates ieri-butyl-3- (cyanomethyl)-3-[4-(7-{[(2,2-dimethylpropanoyl)oxy]methyl}-7H-pyrrolo[2,3-d]pirimidin-4- yl)- lH-pyrazol- l-yl]azetidine-...

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Bibliographische Detailangaben
Hauptverfasser: dr. Volk Balazs, Tothne Dr. Lauritz Maria, dr. Simig Gyula, Kataine Fadgyas Katalin, dr. Nagy Tamas, dr. Dancso Andras, dr. Szabo Eva, dr. Sipos Eva
Format: Patent
Sprache:eng ; hun
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Zusammenfassung:Method and intermediates are disclosed for the production of baricitinib. According to the novel method baricitinib may be produced preferably via the intermediates ieri-butyl-3- (cyanomethyl)-3-[4-(7-{[(2,2-dimethylpropanoyl)oxy]methyl}-7H-pyrrolo[2,3-d]pirimidin-4- yl)- lH-pyrazol- l-yl]azetidine- l-carboxylate and 4-{ 1-[3-(cyanomethyl)azetidin-3-yl]-1H- pyrazol-4-yl}-7H-pyrrolo[2,3-d]pirimidin-7-yl)methyl 2,2-dimethylpropanoate.