PROCESS FOR SEPARATION OF OPTICAL ISOMERS BY LIQUID CHROMATOGRAPHY

PROCESS FOR SEPARATION OF OPTICAL ISOMERS BY LIQUID CHROMATOGRAPHY

The subject of the present invention is the separation of the optical isomers of the racemic hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one ("Corey-lactone") of formula (I), by liquid chromatography. The laevo-rotatory (-) isomer of the compound of formula (I) is a valua...

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Hauptverfasser: MOLNAR ZOLTAN, NAGY MELINDA, STRBKA ANDRASNE, HANAK LASZLO DR, SZABONE RAVASZ BERNADETT DR, KARDOS ZSUZSANNA, NEMETH ATTILA, SZABO TIBOR, SZANYA TIBOR DR, KOZMA GABOR, VAJDA ERVIN, HORVATH GEZA, FONAGY LASZLO
Format: Patent
Sprache:eng
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Zusammenfassung:The subject of the present invention is the separation of the optical isomers of the racemic hexahydro-5-hydroxy-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one ("Corey-lactone") of formula (I), by liquid chromatography. The laevo-rotatory (-) isomer of the compound of formula (I) is a valuable prostaglandin intermediate.