(S)-4-AMINO-5-CHLORO-2-METHOXY-N-{1-[1-(2-TETRAHYDROFURYLCARBONYL)-4-PIPERIDINYLMETHYL]-4-PIPERIDINYL}BENZAMIDE, PROCESS FOR THE PREPARATION THEREOF PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND INTERMEDIATE THEREFOR

(S)-4-AMINO-5-CHLORO-2-METHOXY-N-{1-[1-(2-TETRAHYDROFURYLCARBONYL)-4-PIPERIDINYLMETHYL]-4-PIPERIDINYL}BENZAMIDE, PROCESS FOR THE PREPARATION THEREOF PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND INTERMEDIATE THEREFOR

The compound (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-Ä1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide of the following formula (I): or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, is useful as a gastrointestinal motility enhancer or a gastro...

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Bibliographische Detailangaben
Hauptverfasser: HIROKAWA, YOSHIMI, YOSHIDA, NAOYUKI, MORIKAGE, KAZUO, MORIKAGE, YUKIKO, KATO, SHIRO, YAMAZAKI, HIROSHI, KAN, YOKO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The compound (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-Ä1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide of the following formula (I): or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, is useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent, which shows a potent affinity for 5-HT4 receptor, and shows few effects on the heart, and further shows few side effects on the central nervous system based on the dopamine D2 receptor. A process for preparing the compound, a pharmaceutical composition containing it and an intermediate therefor are also described.