PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-PHENYL]-N-ETHYL-ACETAMIDE (ZALEPLON)
(57) Jelen találmány az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) javított előállítási eljárásáravonatkozik. Az eljárás során N-[3-[3-(dimetilamino)-1-oxo-2-propenil]-fenil]-N-etil-acetamidot vagy sóját 3-amino-4-cianopirazollal vagysójával reagáltatják savas körü...
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| creator | MAGYAR ERIKA KORODI FERENC FEHER ERIKA |
| description | (57) Jelen találmány az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) javított előállítási eljárásáravonatkozik. Az eljárás során N-[3-[3-(dimetilamino)-1-oxo-2-propenil]-fenil]-N-etil-acetamidot vagy sóját 3-amino-4-cianopirazollal vagysójával reagáltatják savas körülmények között, olyan reakcióközegben,ami víz és vízzel elegyedő szerves vegyület elegyét tartalmazza. Ó
The present invention provides a process for the production of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound. |
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The present invention provides a process for the production of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.</description><edition>7</edition><language>eng ; hun</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050228&DB=EPODOC&CC=HU&NR=P0402257A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050228&DB=EPODOC&CC=HU&NR=P0402257A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAGYAR ERIKA</creatorcontrib><creatorcontrib>KORODI FERENC</creatorcontrib><creatorcontrib>FEHER ERIKA</creatorcontrib><title>PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-PHENYL]-N-ETHYL-ACETAMIDE (ZALEPLON)</title><description>(57) Jelen találmány az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) javított előállítási eljárásáravonatkozik. Az eljárás során N-[3-[3-(dimetilamino)-1-oxo-2-propenil]-fenil]-N-etil-acetamidot vagy sóját 3-amino-4-cianopirazollal vagysójával reagáltatják savas körülmények között, olyan reakcióközegben,ami víz és vízzel elegyedő szerves vegyület elegyét tartalmazza. Ó
The present invention provides a process for the production of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNykELgjAYgGEvHaL6D-um0AemiecxP5mw9g2dhykiEusUJtj_Jw_9gE4vD7z7YDY1CWwaVlLNrES2uWiFrUgzKpmGPoUwBeG4JuNq3pGi_nrJgA8bq3tVVBpycCoCI1E7NYAGtNIp4AIt3wZkYccVGkU6Oga75_Ra_enXQ3Au0QoJfnmPfl2mh5_9Z5StiW9xkmQ5T9J_ni9QWzdI</recordid><startdate>20050228</startdate><enddate>20050228</enddate><creator>MAGYAR ERIKA</creator><creator>KORODI FERENC</creator><creator>FEHER ERIKA</creator><scope>EVB</scope></search><sort><creationdate>20050228</creationdate><title>PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-PHENYL]-N-ETHYL-ACETAMIDE (ZALEPLON)</title><author>MAGYAR ERIKA ; KORODI FERENC ; FEHER ERIKA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HUP0402257A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; hun</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MAGYAR ERIKA</creatorcontrib><creatorcontrib>KORODI FERENC</creatorcontrib><creatorcontrib>FEHER ERIKA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAGYAR ERIKA</au><au>KORODI FERENC</au><au>FEHER ERIKA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-PHENYL]-N-ETHYL-ACETAMIDE (ZALEPLON)</title><date>2005-02-28</date><risdate>2005</risdate><abstract>(57) Jelen találmány az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) javított előállítási eljárásáravonatkozik. Az eljárás során N-[3-[3-(dimetilamino)-1-oxo-2-propenil]-fenil]-N-etil-acetamidot vagy sóját 3-amino-4-cianopirazollal vagysójával reagáltatják savas körülmények között, olyan reakcióközegben,ami víz és vízzel elegyedő szerves vegyület elegyét tartalmazza. Ó
The present invention provides a process for the production of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon), an active ingredient that is approved for the treatment of insomnia. The process involves reacting N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethylacetamide or a salt thereof with 3-amino-4-cyanopyrazole or a salt thereof under acidic conditions in a reaction medium comprising a mixture of water and a water-miscible organic compound.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR THE PRODUCTION OF N-[3-(3-CYANOPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-PHENYL]-N-ETHYL-ACETAMIDE (ZALEPLON) |
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