PROCESS FOR THE PREPARATION OF MIDOSTAURIN WITH HIGH PURITY

PROCESS FOR THE PREPARATION OF MIDOSTAURIN WITH HIGH PURITY

A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MIELE, Katia, TOPPINO, Antonio, PAISSONI, Paolo, LENA, Alberto, ROLETTO, Jacopo
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.