METHOD FOR PREPARATION OF PEPTIDES WITH PSWANG LINKER

METHOD FOR PREPARATION OF PEPTIDES WITH PSWANG LINKER

The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CARBAJO LOPEZ, Daniel, ALBERICIO PALOMERA, Fernando, FORNI, Luciano
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated with liraglutide wherein the C-terminal fragment carries the Palmitoyl-Glu-OtBu residue on the Lys.