HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF
The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T...
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| creator | ZENS, Kyra KORMAN, Alan J Thudium, Kent B SELBY, Mark LEBLANC, Heidi YAMANAKA, Mark |
| description | The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody portions of the invention in therapy. |
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Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. 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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF |
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