HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF

HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF

The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZENS, Kyra, KORMAN, Alan J, Thudium, Kent B, SELBY, Mark, LEBLANC, Heidi, YAMANAKA, Mark
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody portions of the invention in therapy.