PROCESSES AND INTERMEDIATES FOR PREPARING A MEDICAMENT

PROCESSES AND INTERMEDIATES FOR PREPARING A MEDICAMENT

Disclosed is a process for the preparation of the following compounds: (I), (II) where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesise downstream products, especially compounds that are useful as medicament...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOUPIS, Ioannis Nicolaos, CONZA, Matteo, PYE, Philip, BEN HAIM, Cyril
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed is a process for the preparation of the following compounds: (I), (II) where R1, R1a and R2a have the definitions in the description, as well as a process to prepare other intermediates that may be useful to synthesise downstream products, especially compounds that are useful as medicaments, for instance Bruton's tyrosine kinase (Btk) inhibitors such as ibrutinib. Also disclosed are other processes, other intermediates and compounds per se.