PHARMACEUTICAL FORMULATIONS OF LORATADINE FOR ENCAPSULATION AND COMBINATIONS THEREOF

This invention relates to a loratadine formulation suitable for encapsulation into a soft gel capsule or suitable dosage unit with improved functionality providing enhancedin vitrodissolution and bioavailability of loratadine. The invention also provides a formulation with improved functionality as...

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Bibliographische Detailangaben
Hauptverfasser:	OKUTAN, Beth, DRAPER, Peter, DRAPER, James
Format:	Patent
Sprache:	eng ; hun
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to a loratadine formulation suitable for encapsulation into a soft gel capsule or suitable dosage unit with improved functionality providing enhancedin vitrodissolution and bioavailability of loratadine. The invention also provides a formulation with improved functionality as a highly concentrated solution within a given fill volume in order to manufacture as small a capsule as possible to facilitate consumer acceptance and acceptable manufacturing costs. The invention also relates to a formulation of optimal stability suitable for supporting a fill composition compatible with the soft gel capsule dosage unit.