PROCESS FOR PREPARING FLUOXASTROBIN

PROCESS FOR PREPARING FLUOXASTROBIN

Provided is a process for preparing fluoxastrobin, comprising: (i) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X1is halogen, with (Z)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (15), optionally in the presence of a solvent and optionally in the presence of...

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Hauptverfasser: HINDUPUR, Rama Mohan, MADDANI, Mahagundappa Rachappa, MANE, Avinash Sheshrao, PAWAR, Jivan Dhanraj, PRASAD, Vic, BALAKRISHNAN, Sankar, WADHWA, Sandeep
Format: Patent
Sprache:eng ; hun
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Zusammenfassung:Provided is a process for preparing fluoxastrobin, comprising: (i) reacting a 4,6-di-halo-5-fluoro-pyrimidine (5), wherein X1is halogen, with (Z)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (15), optionally in the presence of a solvent and optionally in the presence of a base, to form a (Z)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (16):(ii) reacting the (Z)-(2-((6-halo-5-fluoropyrimidin-4-yl)oxy)phenyl)(5,6-dihydro-1,4,2-dioxazin-3-yl)methanone O-methyl oxime (16) with 2-chlorophenol, optionally in the presence of a solvent and optionally in the presence of a base, to form Z)-fluoxastrobin:(iii) isomerizing the (Z)-fluoxastrobin to form fluoxastrobin: