ANTI-CEACAM6 ANTIBODIES AND USES THEREOF
The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreactin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; hun |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GRITZAN, Uwe TRAUTWEIN, Mark GOLFIER, Sven DITTMER, Frank GUTIERREZ, Eva-Maria SCHOENFELD, Dorian WILLUDA, Joerg FREIBERG, Christoph HOLTON, Simon PINKERT, Jessica BECKHOVE, Philip GLUECK, Julian GE, Yingzi |
| description | The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies.The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HUE048111TT2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HUE048111TT2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HUE048111TT23</originalsourceid><addsrcrecordid>eNrjZNBw9Avx1HV2dXR29DVTAHGc_F08XYOBTBeF0GAgI8TDNcjV342HgTUtMac4lRdKczMourmGOHvophbkx6cWFyQmp-allsR7hLoamFgYGhqGhBgZE6MGAO32JEw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTI-CEACAM6 ANTIBODIES AND USES THEREOF</title><source>esp@cenet</source><creator>GRITZAN, Uwe ; TRAUTWEIN, Mark ; GOLFIER, Sven ; DITTMER, Frank ; GUTIERREZ, Eva-Maria ; SCHOENFELD, Dorian ; WILLUDA, Joerg ; FREIBERG, Christoph ; HOLTON, Simon ; PINKERT, Jessica ; BECKHOVE, Philip ; GLUECK, Julian ; GE, Yingzi</creator><creatorcontrib>GRITZAN, Uwe ; TRAUTWEIN, Mark ; GOLFIER, Sven ; DITTMER, Frank ; GUTIERREZ, Eva-Maria ; SCHOENFELD, Dorian ; WILLUDA, Joerg ; FREIBERG, Christoph ; HOLTON, Simon ; PINKERT, Jessica ; BECKHOVE, Philip ; GLUECK, Julian ; GE, Yingzi</creatorcontrib><description>The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies.The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.</description><language>eng ; hun</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200528&DB=EPODOC&CC=HU&NR=E048111T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200528&DB=EPODOC&CC=HU&NR=E048111T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GRITZAN, Uwe</creatorcontrib><creatorcontrib>TRAUTWEIN, Mark</creatorcontrib><creatorcontrib>GOLFIER, Sven</creatorcontrib><creatorcontrib>DITTMER, Frank</creatorcontrib><creatorcontrib>GUTIERREZ, Eva-Maria</creatorcontrib><creatorcontrib>SCHOENFELD, Dorian</creatorcontrib><creatorcontrib>WILLUDA, Joerg</creatorcontrib><creatorcontrib>FREIBERG, Christoph</creatorcontrib><creatorcontrib>HOLTON, Simon</creatorcontrib><creatorcontrib>PINKERT, Jessica</creatorcontrib><creatorcontrib>BECKHOVE, Philip</creatorcontrib><creatorcontrib>GLUECK, Julian</creatorcontrib><creatorcontrib>GE, Yingzi</creatorcontrib><title>ANTI-CEACAM6 ANTIBODIES AND USES THEREOF</title><description>The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies.The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBw9Avx1HV2dXR29DVTAHGc_F08XYOBTBeF0GAgI8TDNcjV342HgTUtMac4lRdKczMourmGOHvophbkx6cWFyQmp-allsR7hLoamFgYGhqGhBgZE6MGAO32JEw</recordid><startdate>20200528</startdate><enddate>20200528</enddate><creator>GRITZAN, Uwe</creator><creator>TRAUTWEIN, Mark</creator><creator>GOLFIER, Sven</creator><creator>DITTMER, Frank</creator><creator>GUTIERREZ, Eva-Maria</creator><creator>SCHOENFELD, Dorian</creator><creator>WILLUDA, Joerg</creator><creator>FREIBERG, Christoph</creator><creator>HOLTON, Simon</creator><creator>PINKERT, Jessica</creator><creator>BECKHOVE, Philip</creator><creator>GLUECK, Julian</creator><creator>GE, Yingzi</creator><scope>EVB</scope></search><sort><creationdate>20200528</creationdate><title>ANTI-CEACAM6 ANTIBODIES AND USES THEREOF</title><author>GRITZAN, Uwe ; TRAUTWEIN, Mark ; GOLFIER, Sven ; DITTMER, Frank ; GUTIERREZ, Eva-Maria ; SCHOENFELD, Dorian ; WILLUDA, Joerg ; FREIBERG, Christoph ; HOLTON, Simon ; PINKERT, Jessica ; BECKHOVE, Philip ; GLUECK, Julian ; GE, Yingzi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HUE048111TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; hun</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GRITZAN, Uwe</creatorcontrib><creatorcontrib>TRAUTWEIN, Mark</creatorcontrib><creatorcontrib>GOLFIER, Sven</creatorcontrib><creatorcontrib>DITTMER, Frank</creatorcontrib><creatorcontrib>GUTIERREZ, Eva-Maria</creatorcontrib><creatorcontrib>SCHOENFELD, Dorian</creatorcontrib><creatorcontrib>WILLUDA, Joerg</creatorcontrib><creatorcontrib>FREIBERG, Christoph</creatorcontrib><creatorcontrib>HOLTON, Simon</creatorcontrib><creatorcontrib>PINKERT, Jessica</creatorcontrib><creatorcontrib>BECKHOVE, Philip</creatorcontrib><creatorcontrib>GLUECK, Julian</creatorcontrib><creatorcontrib>GE, Yingzi</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GRITZAN, Uwe</au><au>TRAUTWEIN, Mark</au><au>GOLFIER, Sven</au><au>DITTMER, Frank</au><au>GUTIERREZ, Eva-Maria</au><au>SCHOENFELD, Dorian</au><au>WILLUDA, Joerg</au><au>FREIBERG, Christoph</au><au>HOLTON, Simon</au><au>PINKERT, Jessica</au><au>BECKHOVE, Philip</au><au>GLUECK, Julian</au><au>GE, Yingzi</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-CEACAM6 ANTIBODIES AND USES THEREOF</title><date>2020-05-28</date><risdate>2020</risdate><abstract>The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies.The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; hun |
| recordid | cdi_epo_espacenet_HUE048111TT2 |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTI-CEACAM6 ANTIBODIES AND USES THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T06%3A46%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GRITZAN,%20Uwe&rft.date=2020-05-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHUE048111TT2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |