ANTI-CEACAM6 ANTIBODIES AND USES THEREOF

ANTI-CEACAM6 ANTIBODIES AND USES THEREOF

The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreactin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GRITZAN, Uwe, TRAUTWEIN, Mark, GOLFIER, Sven, DITTMER, Frank, GUTIERREZ, Eva-Maria, SCHOENFELD, Dorian, WILLUDA, Joerg, FREIBERG, Christoph, HOLTON, Simon, PINKERT, Jessica, BECKHOVE, Philip, GLUECK, Julian, GE, Yingzi
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies.The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.