PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY
PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammal...
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| creator | Svensson, Anders Romagne, François WILKEN, Michael Andre, Pascale Svendsen, Ivan Moretta, Alessandro Gauthier, Laurent Berg Padkaer, Soren Thorolfsson, Matthias Della Chiesa, Mariella Zahn, Stefan Kjaergaard, Kristian Wagtmann, Peter Spee, Pieter |
| description | PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammalian subjects.SOLUTION: The antibody includes antigen binding characteristics similar to antigen binding characteristics of 1-7F9 or 1-4F1 that is a monoclonal antibody of cross-reactivity with KIR2DL1, -2 and -3. There are also provided fragments and derivatives of the antibody; a pharmaceutical composition including the antibody, the fragments and derivatives of the antibody; and the use thereof, especially, the use thereof in treatments to increase natural killer cell activities or cytotoxicity in subjects. |
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There are also provided fragments and derivatives of the antibody; a pharmaceutical composition including the antibody, the fragments and derivatives of the antibody; and the use thereof, especially, the use thereof in treatments to increase natural killer cell activities or cytotoxicity in subjects.</description><language>eng ; hun</language><subject>CHEMISTRY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; TESTING</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200128&DB=EPODOC&CC=HU&NR=E045639T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200128&DB=EPODOC&CC=HU&NR=E045639T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Svensson, Anders</creatorcontrib><creatorcontrib>Romagne, François</creatorcontrib><creatorcontrib>WILKEN, Michael</creatorcontrib><creatorcontrib>Andre, Pascale</creatorcontrib><creatorcontrib>Svendsen, Ivan</creatorcontrib><creatorcontrib>Moretta, Alessandro</creatorcontrib><creatorcontrib>Gauthier, Laurent</creatorcontrib><creatorcontrib>Berg Padkaer, Soren</creatorcontrib><creatorcontrib>Thorolfsson, Matthias</creatorcontrib><creatorcontrib>Della Chiesa, Mariella</creatorcontrib><creatorcontrib>Zahn, Stefan</creatorcontrib><creatorcontrib>Kjaergaard, Kristian</creatorcontrib><creatorcontrib>Wagtmann, Peter</creatorcontrib><creatorcontrib>Spee, Pieter</creatorcontrib><title>PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY</title><description>PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammalian subjects.SOLUTION: The antibody includes antigen binding characteristics similar to antigen binding characteristics of 1-7F9 or 1-4F1 that is a monoclonal antibody of cross-reactivity with KIR2DL1, -2 and -3. 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| subjects | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| title | PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY |
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