PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY

PAN-KIR2DL NK-RECEPTOR ANTIBODIES AND THEIR USE IN DIAGNOSTIK AND THERAPY

PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammal...

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Bibliographische Detailangaben
Hauptverfasser: Svensson, Anders, Romagne, François, WILKEN, Michael, Andre, Pascale, Svendsen, Ivan, Moretta, Alessandro, Gauthier, Laurent, Berg Padkaer, Soren, Thorolfsson, Matthias, Della Chiesa, Mariella, Zahn, Stefan, Kjaergaard, Kristian, Wagtmann, Peter, Spee, Pieter
Format: Patent
Sprache:eng ; hun
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammalian subjects.SOLUTION: The antibody includes antigen binding characteristics similar to antigen binding characteristics of 1-7F9 or 1-4F1 that is a monoclonal antibody of cross-reactivity with KIR2DL1, -2 and -3. There are also provided fragments and derivatives of the antibody; a pharmaceutical composition including the antibody, the fragments and derivatives of the antibody; and the use thereof, especially, the use thereof in treatments to increase natural killer cell activities or cytotoxicity in subjects.