ARYL ETHERS AND USES THEREOF

ARYL ETHERS AND USES THEREOF

The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice...

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Hauptverfasser: YANG, Hanbiao, XU, Rui, DIXON, Darryl David, GRINA, Jonas, WANG, Bin, WEHN, Paul, JOSEY, John A, RIZZI, James P, WALLACE, Eli, SCHLACHTER, Stephen
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creator YANG, Hanbiao
XU, Rui
DIXON, Darryl David
GRINA, Jonas
WANG, Bin
WEHN, Paul
JOSEY, John A
RIZZI, James P
WALLACE, Eli
SCHLACHTER, Stephen
description The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.
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title ARYL ETHERS AND USES THEREOF
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