ARYL ETHERS AND USES THEREOF

ARYL ETHERS AND USES THEREOF

The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YANG, Hanbiao, XU, Rui, DIXON, Darryl David, GRINA, Jonas, WANG, Bin, WEHN, Paul, JOSEY, John A, RIZZI, James P, WALLACE, Eli, SCHLACHTER, Stephen
Format: Patent
Sprache:eng ; hun
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present disclosure relates to HIF-2a inhibitors and methods of making and using them for treating cancer. Certain compounds were potent in HIF-2a scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and led to tumor size reduction and regression in 786-O xenograft bearing mice in vivo.