PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE

PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE

The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoet...

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Bibliographische Detailangaben
Hauptverfasser: MERTEN, Joern, LINZ, Guenter, REICHEL, Carsten, SCHIFFERS, Robert, SCHMID, Rolf, RENNER, Svenja, RALL, Werner, SCHNAUBELT, Juergen
Format: Patent
Sprache:eng ; hun
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Zusammenfassung:The present invention relates to a process for the manufacture of a specific indolinone derivative and a pharmaceutically acceptable salt thereof, namely 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone and its monoethanesulfonate, to new manufacturing steps and to new intermediates of this process.