Dispiro 1,2,4 - trioxolane antimalarials

A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl...

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Bibliographische Detailangaben
Hauptverfasser:	Charman, William N.,Victorian College of Pharmacy, Yatendra, Kumar, Gyan, Chand Yadav, Tang, Yuanquing,University of Nebraska Medic.Cen, Vennerstrom, Jonathan L.,Univ.of Nebraska Med. C, Dong, YuxiangUniversity of Nebraska Medic.Center, Padmanilayam, Maniyan, Chollet, Jaques,Swiss Tropical Institute, Matile, Hughes,Pharma Research Department
Format:	Patent
Sprache:	eng ; hun
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.