Methods and reagents for efficient and targeted gene transfer to cells of monocyte-macrophage lineage
The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the shor...
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| Format: | Patent |
| Sprache: | eng ; hun |
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| Zusammenfassung: | The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells. |
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