AZAINDAZOLE COMPOUNDS AND METHODS OF USE

AZAINDAZOLE COMPOUNDS AND METHODS OF USE

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assa...

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Bibliographische Detailangaben
Hauptverfasser: LELETI, Manmohan R, PENNELL, Andrew M. K, LI, Lianfa, LI, Yandong, ZHANG, Penglie, WRIGHT, John J. Kim, XU, Yuan, CHEN, Wei
Format: Patent
Sprache:eng ; hun
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Zusammenfassung:Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.