Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage

The present invention relates to a method for improving the solubility of a physiologically active protein or peptide compared to that of a physiologically active protein or peptide which is not conjugated to an immunoglobulin Fc fragment, in which the method comprises conjugating the physiologicall...

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Bibliographische Detailangaben
Hauptverfasser: Kim Dae Jin, Bae Sung Min, Kwon Se Chang, Lim Hyung Kyu, Jung Sung Youb Suji-gu, Lee Jong Soo
Format: Patent
Sprache:eng ; hun
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Beschreibung
Zusammenfassung:The present invention relates to a method for improving the solubility of a physiologically active protein or peptide compared to that of a physiologically active protein or peptide which is not conjugated to an immunoglobulin Fc fragment, in which the method comprises conjugating the physiologically active protein or peptide to an immunoglobulin Fc fragment; and a composition for improving the solubility of a physiologically active protein or peptide, comprising an immunoglobulin Fc fragment, in which the composition improves the solubility compared to a composition without an immunoglobulin Fc fragment..