Improved process for producing pharmaceutical agent prasugrel and 2-(2-fluorophenyl)-1-cyclopropylethanone intermediate

Improved process for producing pharmaceutical agent prasugrel and 2-(2-fluorophenyl)-1-cyclopropylethanone intermediate

The invention relates to an industrial scale process for the preparation of 1-cyclopropyl-2-(2-fluorophenyl)ethanone of Formula (1) (Formula (1)) and the use of this compound for the preparation of 2-acetoxy-5-(2- fluoro-α-cyclopropylcarbonylbenzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasu...

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Bibliographische Detailangaben
Hauptverfasser: dr. Volk Balazs, Ruzsics Gyoergy, Kovacs Edina, Varady Karolyne, dr. Lukacs Gyula, dr. Porcs-Makkay Marta, Pakaine Varga Gabriella, Nyulasi Balint, dr. Szabo Eva
Format: Patent
Sprache:eng ; hun
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to an industrial scale process for the preparation of 1-cyclopropyl-2-(2-fluorophenyl)ethanone of Formula (1) (Formula (1)) and the use of this compound for the preparation of 2-acetoxy-5-(2- fluoro-α-cyclopropylcarbonylbenzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of Formula (5). ((Formula (5))