A new bis-indole alkaloids as anticancer drugs

The field of this invention relates to novel cyclopropyl derivatives of the general formula (I) representing pharmaceutically applicable Vinca Rosea type alkaloid compounds, particularly having a cytostatic effect. The invention also is concerned processes for preparing these new alkaloids and their...

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Bibliographische Detailangaben
Hauptverfasser:	HAZAI LASZLO, KEGLEVICH PETER, SZANTAY CSABA, KALAUS GYOERGY
Format:	Patent
Sprache:	eng ; hun
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The field of this invention relates to novel cyclopropyl derivatives of the general formula (I) representing pharmaceutically applicable Vinca Rosea type alkaloid compounds, particularly having a cytostatic effect. The invention also is concerned processes for preparing these new alkaloids and their pharmacological compositions and the use of these compounds in treatment of cancer. R stands for a methyl or a formyl group, R1 stands for a methoxy or an amino group, R2 represents a hydroxy or acetoxy group, R3 stands for a hydrogen atom or a hydroxy group, R4 represents a hydrogen atom or R3 and R4 together represent a double bond, R5 and R6 represent hydrogen or fluorine atoms n = 1 or 2.