KINAZOLINE DERIVATIVES AS IRREVERSIBLE INHIBITORS OF PROTEIN-KINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USE THEREOF

The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the tr...

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Hauptverfasser:	DENNY, WILLIAM ALEXANDER, DOBRUSIN, ELLEN MYRA, FRY, DAVID WILLIAM, MCNAMARA, DENNIS JOSEPH, SHOWALTER, HOWARD DANIEL HOLLIS, SMAILL, JEFFREY B, BRIDGES, ALEXANDER JAMES, DOHERTY, ANNETTE MARIAN, ZHOU, HAIRONG
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	DENNY, WILLIAM ALEXANDER DOBRUSIN, ELLEN MYRA FRY, DAVID WILLIAM MCNAMARA, DENNIS JOSEPH SHOWALTER, HOWARD DANIEL HOLLIS SMAILL, JEFFREY B BRIDGES, ALEXANDER JAMES DOHERTY, ANNETTE MARIAN ZHOU, HAIRONG
description	The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.
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The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.</abstract><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	KINAZOLINE DERIVATIVES AS IRREVERSIBLE INHIBITORS OF PROTEIN-KINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USE THEREOF
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