KINAZOLINE DERIVATIVES AS IRREVERSIBLE INHIBITORS OF PROTEIN-KINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USE THEREOF

KINAZOLINE DERIVATIVES AS IRREVERSIBLE INHIBITORS OF PROTEIN-KINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND USE THEREOF

The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the tr...

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Bibliographische Detailangaben
Hauptverfasser: DENNY, WILLIAM ALEXANDER, DOBRUSIN, ELLEN MYRA, FRY, DAVID WILLIAM, MCNAMARA, DENNIS JOSEPH, SHOWALTER, HOWARD DANIEL HOLLIS, SMAILL, JEFFREY B, BRIDGES, ALEXANDER JAMES, DOHERTY, ANNETTE MARIAN, ZHOU, HAIRONG
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.