NOVEL 1-[1-(HETERO)-ARIL-1-PERHYDROXY-ALKYL-METHYL]-PIPERAZINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of form...

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Hauptverfasser:	PREUSCHOFF, ULF DR, DAVID, SAMUEL, REICHE, DANIA DR, ANTEL, JOCHEN DR, SANN, HOLGER DR, BRUECKNER, REINHARD DR, EECKHOUT, CHRISTIAN, JASSERAND, DANIEL DR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of formula (I) and their acid addition salts are new. A = naphthyl, phenyl (optionally substituted by OH), mono- or bi-cyclic heteroaryl or 3-6C alkenyl (optionally substituted by phenyl); Q = (CHOR1)k-(CHOR2)l-(CHOR3)m-(CHOR4)n-CH2OR5 ; R1-R5 = H or lower alkanoyl, or two of R1-R5 = CO, CS or CH2 (optionally substituted by lower alkyl or 4-5C alkylene), completing a 5- or 6-membered ring; k, l, m, n = 0 or 1, and R6, R7 = H or halo. Independent claims are also included for: (1) the preparation of (I), and (2) new piperazine derivative intermediates of formula (II).