PROCESS FOR PRODUCING RECONSTITUTED LIPOPROTEINE

Industrial prodn. of a compsn. (A), contg. reconstituted lipoprotein particles (LPP), comprises first mixing an aq. apolipoprotein (APL) soln. of protein content 1-40 g/l with an aq. lipid(L)-detergent (D) soln., at mole ratio L:D 1:0.5-4 and wt. ratio APL:L 1:1.5-5.The resulting mixt. was incubated...

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Bibliographische Detailangaben
Hauptverfasser:	FOERTSCH, VRENI, HODLER, GERHARD, LERCH, PETER DR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Industrial prodn. of a compsn. (A), contg. reconstituted lipoprotein particles (LPP), comprises first mixing an aq. apolipoprotein (APL) soln. of protein content 1-40 g/l with an aq. lipid(L)-detergent (D) soln., at mole ratio L:D 1:0.5-4 and wt. ratio APL:L 1:1.5-5.The resulting mixt. was incubated at a temp. within 10 degrees C of the phase transition temp. of L in water, then the detergent removed (by exclusion according to mol. size or by using an adsorbent) so that LPP of dia. 5-50 nm and mol.wt. 0.05-1 MD are formed. Without further purificn. steps, over 95% of added protein and over 90% of total L is bound in LPP.Opt. the resulting liq. prod. is lyophilised in presence of a carbohydrate stabiliser.(A) contains 18-22 g/l protein and, at 18-22 degrees C, has turbidity below 40 NTV.