PROCESS FOR PREPARING 21-CHLORO-CORTICOSTEROIDS

PROCESS FOR PREPARING 21-CHLORO-CORTICOSTEROIDS

Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEE, JUNNING, COLON, CESAR, TANN, CHOU-HONG, FU, XIAOYONG, THIRUVENGADAM, TIRUVETTIPURAM K
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl5, PCl3, POCl3 or either SO2Cl2 and imidazole, or PPh3 and CCl4. The disclosed process selectively forms DELTA steroids from either 11- alpha - or 11- beta -hydroxy steroids, and can also be used for the one-step conversion of 11,21-dihydroxy steroids to 21-chloro- DELTA steroids. Also disclosed are processes for the regioselective conversion of 11- beta -chloro steroids to DELTA steroids, and for regioselectively converting an 11,17,21-trihydroxy steroid to a 21-chloro-11,17-dihydroxy steroid.