PROCESS FOR PRODUCING (1S,4R)- OR (1R,4S)-4-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL

PROCESS FOR PRODUCING (1S,4R)- OR (1R,4S)-4-(2-AMINO-6-CHLORO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL

Racemic or optically active 1-amino-4-(hydroxymethyl)-2- cyclopentene derivatives are obtained by acylation of 1-amino-2-cyclopentene-4- carboxylic acid with an acid halide, followed by reduction of the carboxyl group. A method for the production of racemic or optically active 4-(hydroxymethyl)-2-cy...

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Hauptverfasser: BURGDORF, KURT, BIRCH, OLWEN MARY DR, BRUX, FRANK, ETTER, KAY-SARA, BOSSARD, PIERRE DR, O'MURCHU, COLM DR, BRIEDEN, WALTER DR, GORDON, JOHN, GUGGISBERG, YVES DR, BERNEGGER, CHRISTINE DR, URBAN, EVA MARIA, DUC, LAURENT DR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROCESSES USING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:Racemic or optically active 1-amino-4-(hydroxymethyl)-2- cyclopentene derivatives are obtained by acylation of 1-amino-2-cyclopentene-4- carboxylic acid with an acid halide, followed by reduction of the carboxyl group. A method for the production of racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivatives of formula (XIII) involves acylation of a cyclopentene-4-carboxylic acid derivative of formula (XIV) (as the racemate or an optically active isomer) with a carboxylic acid halide of formula R1>-CO-X (XI), followed by reduction of the resulting acid derivative (XV): [Image] R1>1-4C alkyl, 1-4C alkoxy, aryl or aryloxy; X : halogen.