PROCESS FOR PRODUCING SPIRO[CIS-4-(BETHA-HYDROXY-ETHYLOXI)-CYCLOHEXANE-[3H]INDOLE]-2'[1'H]-ONE DERIVATIVES

PROCESS FOR PRODUCING SPIRO[CIS-4-(BETHA-HYDROXY-ETHYLOXI)-CYCLOHEXANE-[3H]INDOLE]-2'[1'H]-ONE DERIVATIVES

The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2...

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Hauptverfasser: HERMECZ ISTVAN DR, HAJDU FELIX, NAGY LAJOS, SZVOBODA GYOERGYNE, KIS LASZLO, GOENCZI CSABA DR, HEJA GERGELY DR, SZOMOR TIBORNE, HALASZ JUDIT, SANTANE CSUTOR ANDREA, CSIKOS EVA, SIMON KALMAN DR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of spiro[cis-4-(beta-hydroxyethyloxy)cyclohexane-[3H]indol]-2'[1'H]-one derivatives of the formula (I) wherein R1 and R2 are as defined herein, by reduction of a dispiro[(1,3-dioxolane)-2,4'-cyclohexane-1'3'-[3H]indol]-2''[1''H]-one derivative of general formula (II), wherein R1 and R2 are as defined herein, which comprises carrying out the reduction (a) with sodium cyanoborohydride in the presence of a Lewis acid, or (b) with sodium borohydride in the presence of a strong acid.