BENZODIOXAN, BENZOFURAN AND BENZOPYRAN DERIVATIVES HAVING FUNDIC RELAXATION PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk is C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy or C1-4alkylcarbonyloxy; -Z -Z - is a bivalent radical; R , R and R are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R and R are on adjacent carbon atoms, R and R taken together may form a bivalent radical; R is hydrogen or C1-6alkyl; A is a bivalent radical of formula -NR -Alk -(b-1), or -Npiperidinyl-(CH2)m (b-2) wherein m is 0 or 1; R is a radical of formulawherein n is 1 or 2; p is 0, and p is 1 or 2; or p is 1 or 2, and p is 0; X is oxygen, sulfur or =NR ; Y is oxygen or sulfur; R is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.