PROCESS FOR THE PRODUCTION OF SELESTIVE ADENOZINE ANTAGONISTIC XANTINE DERIVATIVES AND MEDICAL PREPARATIONS CONTAINING THEM AS ACTIVE AGENTS

Xanthine derivatives which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro...

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Bibliographische Detailangaben
Hauptverfasser: PEET,NORTON PAUL,US, LENTZ,NELSEN LOWELL,US
Format: Patent
Sprache:eng
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Zusammenfassung:Xanthine derivatives which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo. Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.