PROCESS FOR PRODUCING HISTAMINE H1 ANTAGONISTIC PURINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

PROCESS FOR PRODUCING HISTAMINE H1 ANTAGONISTIC PURINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention concerns histamine H1-receptor antagonists of the formula: where R is hydrogen or alkyl; one of R and R is alkyl and the other is where R is pyridin-2-yl, pyridin-4-yl, thienyl, or phenyl, any of which is optionally substituted by a halo, alkyl of 1 to 6 carbon atoms, nitro, trifluorom...

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Bibliographische Detailangaben
Hauptverfasser: NIELSEN,SUSAN TH.,US, ABOU-GHARBIA,MAGID A.,US, WEBB,MICHAEL B.,US
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention concerns histamine H1-receptor antagonists of the formula: where R is hydrogen or alkyl; one of R and R is alkyl and the other is where R is pyridin-2-yl, pyridin-4-yl, thienyl, or phenyl, any of which is optionally substituted by a halo, alkyl of 1 to 6 carbon atoms, nitro, trifluoromethyl, hydroxy or alkoxy of 1 to 6 carbon atoms substituent; and R is pyridin-2-yl, pyridin-4-yl or phenyl, any of which is optionally substituted by a halo, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro or trifluoromethyl substituent.