PROCESS FOR PREPARING ALPHA-L HUMAN LEUKOCYTE INTERFERONE

A method for producing human leukocyte interferon alpha-2 resides in that there is carried out submerged cultivation of a producer strain Pseudomonas species VG-84 carrying a plasmid pVG3 with an inserted gene of human leukocyte interferon alpha-2, said strain being deposited in the collection of mi...

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Hauptverfasser:	CARJOV,SERGEJ A.,SU, SVERDLOV,JEVGENIJ D.,SU, SALOMATINA,IRINA S.,SU, KOZLOV,JURIJ I.,SU, STERKIN,VIKTOR E.,SU, CYGANKOV,JURIJ D.,SU, IZOTOVA,LARA S.,SU, DEBABOV,VLADIMIR G.,SU, MONASTYRSKAYA,GALINA S.,SU, KUZNECOV,VLADIMIR P.,SU, DOLGANOV,GRIGOR M.,SU, STRONGIN,ALEXANDR J.,SU, OGARKOV,VSEVOLOD I.,SU, BELJAEV,SERGEJ V.,SU, OVCHINNIKOV,JURIJ A.,SU, CHRISTOSERDOV,ANDREJ J.,SU, KOSTROV,SERGEJ V.,SU, ARSENJAN,SERGEJ G.,SU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method for producing human leukocyte interferon alpha-2 resides in that there is carried out submerged cultivation of a producer strain Pseudomonas species VG-84 carrying a plasmid pVG3 with an inserted gene of human leukocyte interferon alpha-2, said strain being deposited in the collection of microorganism cultures at the USSR Antibiotics Research Institute under Reg. No. 1742; said strain being cultivated in a nutrient medium, containing the sources of carbon and nitrogen, mineral salts and growth stimulants, under aeration in the presence of antibiotics, i.e., streptomycin or tetracycline, or a mixture of both, followed by isolation and purification of the end product.