PROCESS FOR PRODUCTION OF NEW, IN 11-POSITION SUBSTITUATED 5,11-DIHYDRO-6H-PIRIDO /2,3-B//1,4/-BENZODIOZEPIN-6-ON AND MEDICAL COMPOUNDS CONTAINING THEREOF

PROCESS FOR PRODUCTION OF NEW, IN 11-POSITION SUBSTITUATED 5,11-DIHYDRO-6H-PIRIDO /2,3-B//1,4/-BENZODIOZEPIN-6-ON AND MEDICAL COMPOUNDS CONTAINING THEREOF

Compounds of general formula I are described, (I) wherein X represents the group =CHR, =NR or an oxygen atom and A represents the groups -NR1R2, wherein R1 and R2 represent alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R3 represents a hydrogen atom, a hydroxy or alkyl g...

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Hauptverfasser: ENGEL,WOLARD,DE, MIHM,GERHARD,DE, HAMMER,RUDOLF,DE, EBERLEIN,WOLFGANG,DE, BALLHAUSE,HELMUT,DE, GIACHETTI,ANTONIO,DE, TRUMMLITZ,GUENTHER,DE, MAYER,NORBERT,DE, DE JONGE,ARIAAN,DE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds of general formula I are described, (I) wherein X represents the group =CHR, =NR or an oxygen atom and A represents the groups -NR1R2, wherein R1 and R2 represent alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R3 represents a hydrogen atom, a hydroxy or alkyl group or a group -(CH2)n-N-R5R6 (R5 and R6 being lower alkyl groups) and R4 is an alkyl or phenylalkyl group; two processes for preparing these compounds and the salts thereof are also described. The compounds have favourable effects on heart rate and can be used as vagal pacemakers for treating bradycardia and bradyarrhythmia in human and veterinary medicine. Some of these compounds also have very good antithrombotic effects.