PROCESS FOR PRODUCING NEW CARBACYCLINE ESTERS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Carbacyclin esters of Formula I wherein R1 is an unsubstituted or substituted aromatic residue, R2 is a free or functionally modified hydroxy group, R3 is an alkyl or cycloalkyl group, or an optionally substituted aryl group, or a heterocyclic group, X is oxygen atom or the group -CH2-, A is a -CH2-...

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Bibliographische Detailangaben
Hauptverfasser:	SKUBALLA,WERNER,DE, TOWN,MICHAEL-HAROLD,DE, VORBRUEGGEN,HELMUT,DE, MANNESMANN,GERHARD,DE, NIEUWEBOER,BOB,DE, RADUECHEL,BERNO,DE
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Carbacyclin esters of Formula I wherein R1 is an unsubstituted or substituted aromatic residue, R2 is a free or functionally modified hydroxy group, R3 is an alkyl or cycloalkyl group, or an optionally substituted aryl group, or a heterocyclic group, X is oxygen atom or the group -CH2-, A is a -CH2-CH2-, trans-CH=CH-, or -C IDENTICAL C-group, W is a free or functionally modified hydroxy-methylene group or a free or functionally modified wherein the OH-group can be in the alpha - or beta -position, D is the group a straight-chain saturated alkylene group of 1-5 carbon atoms, a branched, saturated or a straight-chain or branched, unsaturated alkylene group of 2-5 carbon atoms, which groups can optionally be substituted by fluorine atoms, E is a direct bond, a -C IDENTICAL C- group, or a -CR4=CR5- group wherein R2 and R5 mean a hydrogen atom or an alkyl group of 1-5 carbon atoms; are useful as blood-pressure-lowering agents, inter alia.